Coarse Master Equations for Binding Kinetics of Amyloid Peptide Dimers

Coarse graining of master equations with fast and slow states.

We propose a general method for simplifying master equations by eliminating from the description rapidly evolving states. The physical recipe we impose is the suppression of these states and a renormalization of the rates of all the surviving states. In some cases, this decimation procedure can be analytically carried out and is consistent with other analytical approaches, such as in the proble...

Serum Amyloid A Binding to Formyl Peptide

Application of FITC for detecting the binding of antiangiogenic peptide to HUVECs

Angiogenesis is the generation of new blood vessels from the existing vasculature. The angiogenic programme requires the degradation of the basement membrane, endothelial cell migration and invasion of the extracellular matrix, with endothelial cell proliferation and capillary lumen formation before maturation and stabilization of the new vasculature. Angiogenesis is dependent on a delicate equ...

Coarse Grained Molecular Kinetics

The dynamic behavior of molecules can often be described by Markov processes. From computational molecular simulations one can derive transition rates or transition probabilities between subsets of the discretized conformational space. On the basis of this dynamic information, the spatial subsets are combined into a small number of so-called metastable molecular conformations. This is done by c...

On the Performance of Different Empirical Loss Equations for Flow Through Coarse Porous Media (RESEARCH NOTE)

In this paper, the empirical equations that estimate hydraulic parameters for non-linear flow through coarse porous media are evaluated using a series of independent data collected in the laboratory. In this regard, three different relatively uniform soils ranging in size from 8.5 to 27.6 mm have been selected and three random samples drawn from each material. The physical characteristics such ...